Prophylactic – Communicable Diseases Research

Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Article

Published on 2022-12-012022-11-15
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody neutralizing antibody. omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type
[DOI] 10.1080/22221751.2022.2117094 PMC 바로가기

An efficient approach for SARS-CoV-2 monoclonal antibody production via modified mRNA-LNP immunization

Article

Published on 2022-11-052022-11-15
Journal: International journal of pharmaceutics
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] addition Antigen antigens applied approach approaches binding affinity circumvent complementary COVID-19 COVID-19 pandemic Delta Diseases evaluated functional fusion strategy generate immunization introduced lack Lipid Lipid nanoparticle (LNP) LNP mAb mAbs Membrane proteins methodology mice Modified mRNA monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity posttranslational modification Prophylactic Protein RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2 virus SARS-CoV-2. serum serum antibody several variants therapeutic drug Treatment Vaccines variants
[DOI] 10.1016/j.ijpharm.2022.122256 PMC 바로가기

Central Retinal Vein Occlusion After Discontinuation of Rivaroxaban Therapy in a Young Patient with COVID-19 Pulmonary Embolism: A Case Report

Article

Published on 2022-11-012022-11-15
Journal: The American journal of case reports
[Category] 진단,

Integrating in silico and in vivo approach for investigating the role of polyherbal oil in prevention and treatment of COVID-19 infection

Article

Published on 2022-11-012022-11-15
Journal: Chemico-biological interactions
[Category] SARS, 변종, 치료제,

[키워드] ACE2 Analysis angiotensin-converting enzyme 2 Anti-inflammatory anti-inflammatory activity antiviral drug approach approved combating Compound contribute Control COVID-19 COVID-19 infection COVID-19 patients cytokine Efficacy ELIXIR entry of SARS-CoV-2 expression FDA GC-MS group groups hamster hamsters human host in silico in vivo in-silico Infection inhibiting inhibitory effect investigated Lung injury male membrane molecular docking molecular docking studies new SARS-CoV-2 PCR Polyherbal oil Prophylactic Protective real time receptor reduced respiratory diseases SARS-CoV-2 selected significantly Spike protein the SARS-CoV-2 Therapeutics Therapeutics. these compound treat Treatment treatment groups Vaccine variants viral envelope Viral load
[DOI] 10.1016/j.cbi.2022.110179 PMC 바로가기

Breakthrough COVID-19 cases despite prophylaxis with 150 mg of tixagevimab and 150 mg of cilgavimab in kidney transplant recipients

Article

Published on 2022-11-012022-11-15
Journal: American journal of transplantation : official jou
[Category] COVID19(2023년), SARS, 변종, 진단,

Effectiveness of COVID-19 mRNA Vaccines Against COVID-19-Associated Hospitalizations Among Immunocompromised Adults During SARS-CoV-2 Omicron Predominance – VISION Network, 10 States, December 2021-August 2022

Article

Published on 2022-10-212022-11-15
Journal: Morbidity and Mortality Weekly Report
[Category] COVID19(2023년), SARS, 변종, 치료제,

Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected During the 2020 Pandemic

Article

Published on 2022-10-172022-11-15
Journal: The Journal of Infectious Diseases
[Category] COVID19(2023년), SARS, 진단,

DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2

Article

Published on 2022-10-062022-11-15
Journal: Nature Communications
[Category] COVID19(2023년), SARS, 진단, 치료제,

Care for adults with COVID-19: living guidelines from the National COVID-19 Clinical Evidence Taskforce

Article

Published on 2022-10-032022-11-15
Journal: The Medical journal of Australia
[Category] COVID19(2023년), SARS, 진단,

[키워드] Analysis anticoagulation Antiviral agents Baricitinib benefit change clinical clinical trial Combination coronavirus disease Corticosteroids COVID-19 disease disease severity drug treatment eight Endotracheal intubation Evidence facilitated Health include Inhaled maintain management Mild molnupiravir nine Patient people with COVID-19 positive airway pressure Primary Health Care prone positioning Prophylactic Prophylaxis Public public health. randomised recommendation recommendations Remdesivir Respiratory Support sarilumab subsequent supplemental oxygen Support supportive care systemic corticosteroids therapy Tocilizumab Treatment trials Venous Thromboembolism with COVID-19
[DOI] 10.5694/mja2.51718 PMC 바로가기

Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticals

Article

Published on 2022-10-012022-11-15
Journal: Journal of food biochemistry
[Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] affinity Antiviral antiviral agent apigenin binding binding domain binding interaction biological activity C-terminal Cancer Cancer cells candidate carried cell line cell lines cells Cinnamomum cinnamon complex Complexes components Compound computational analysis computational approach CTD cytotoxicity death drug candidate Druglikeness effective Efficacy evaluate evaluated examined greater HPLC in silico in vitro in vivo Interaction lack less molecular molecular dynamics MTT N-terminal Naturally NTD nucleocapsid nutraceutical oregano Origanum outcome parsley. plant predicted profile Prophylactic Protein provided Research responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein stability symptomatic targets therapeutic therapeutic drug therapy Toxicity treating COVID-19 Treatment virus was determined was performed worsened
[DOI] 10.1111/jfbc.14262 PMC 바로가기